In December 1902, U.S. public health authorities reported progress in smallpox vaccination campaigns that had intensified after outbreaks in several cities. Local and federal officials stressed the importance of vaccination to prevent deadly epidemics. These reports reflected decades of work to promote vaccines in the United States. The progress shown that month indicated rising public acceptance of vaccination despite ongoing pockets of resistance. Over time, sustained campaigns led to the eradication of smallpox worldwide. December efforts fit within a larger pattern of U.S. leadership in disease prevention and public health policy.